Wednesday, September 5, 2007

Craig Venter's Genome


Finally, Craig Venter (aka, the Darth Vader of Genetics) got his genome fully sequenced and published. Both Nature and Science magazines reported it as news once this PLoS Biology article is on-lined.

It had been criticized by Science magazine editor that Craig Ventor's move as a "tacky move" to make himself as one of the five donors in the Human Genome Project.

And, of course, how can we miss this article in which Craig Venter was criticized by another editor -
I'm the human genome, says 'Darth Venter' of genetics
Robin McKie, science editor


Therefore, I am totally not surprised that Craig Venter has his personal genome fully sequenced.

Compared the news report from Science and Nature, the latter seems to hold a more friendly position to describe the news.

Not surprisingly, another famous ass hole will be fully sequenced pretty soon. His name is James D. Watson. Why can't we just spend our money on sequencing a relative NICE/GOOD guy's genome???
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Here are more discussions about the news of Craig Venter's Genome
The Seven Stones
CNN Anderson Cooper Blog
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The summary of yesterday's Craig Venter Genome article on PLoS Biology:

We have generated an independently assembled diploid human genomic DNA sequence from both chromosomes of a single individual (J. Craig Venter). Our approach, based on whole-genome shotgun sequencing and using enhanced genome assembly strategies and software, generated an assembled genome over half of which is represented in large diploid segments (>200 kilobases), enabling study of the diploid genome. Comparison with previous reference human genome sequences, which were composites comprising multiple humans, revealed that the majority of genomic alterations are the well-studied class of variants based on single nucleotides (SNPs). However, the results also reveal that lesser-studied genomic variants, insertions and deletions, while comprising a minority (22%) of genomic variation events, actually account for almost 74% of variant nucleotides. Inclusion of insertion and deletion genetic variation into our estimates of interchromosomal difference reveals that only 99.5% similarity exists between the two chromosomal copies of an individual and that genetic variation between two individuals is as much as five times higher than previously estimated. The existence of a well-characterized diploid human genome sequence provides a starting point for future individual genome comparisons and enables the emerging era of individualized genomic information.

1 comment:

Joseph said...

He looks like twoface in this picture.