Are Open-Access Journals not Popular among Scientists ?

I strongly feel I should at least mention something related to sciences on TGIF. Unfortunately the theory lunch has not started yet. So let's take a look on the article in my A-log.

Scientists are wary of open-access journals

I am kind of at a stage choosing journals. Basically what this article said is very close to what I've heard here. My problem is my manuscript is too big for most "higher" profile journals and probably the no-limitation PLoS Biology will be an option at the end.

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Scientists are wary of open-access journals'. Research Information 2007; 30:5.

A recent study from researchers at University of Arkansas at Little Rock and the University of Munich, showed that researchers are reluctant to publish their research within open-access outlets, even if open-access publications have higher speed of publication and citation rates. According to this study academics are positive about the speed at which online journals spread new findings to academic world, but more than 50% of them said that open-access is not well-known enough to use it as a medium for publishing works, and that open-access publications lack a guarantee of long term availability of research. This situation suggests a gap between positive attitude toward open-access publication and a low level of use of this means.