Uri Alon 打書廣告

今天竟然收到 Uri Alon 的 E-mail，原來是他的書要出版了寫來打書的。不過還是很怪，寄給我做啥？如果我都有收到，那麼收信人可能有上千人吧！Anyway，有興趣的可以留意一下。

Uri Alon 可以說是 Systems Biology 裡面響噹噹的一號人物，我還在台灣的時候就看過他 yeast genome-wide protein-protein interaction screening 的 paper。我們 department 裡以色列人不少，幾乎都是從 Weizmann Institute 來的，三不五時還有人過來演講或做訪問學者。以色列這麼小個地方又處在戰亂威脅下科研能做得著麼好，不知原因是甚麼？
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Hi,

I'm happy to say that my new book, "An Introduction to Systems
Biology: Design Principles of Biological Circuits" has just been published by Chapman & Hall/CRC.
This book was a pleasure to write and to teach with.

Yours,
Uri.

For details, please see
http://www.crcpress.co.uk/shopping_cart/products/product_reviews.asp?id=&parent_id=&sku=C6420&pc=

Contents
INTRODUCTION

TRANSCRIPTION NETWORKS, BASIC CONCEPTS
Introduction
The Cognitive Problem of the Cell
Elements of Transcription Networks
Dynamics and Response Time of Simple Gene Circuits

AUTO-REGULATION, A NETWORK MOTIF
Introduction
Patterns, Randomized Networks and Network Motifs
Autoregulation is a Network Motif
Negative Auto-Regulation Speeds the Response Time of Gene
Circuits
Negative Auto-Regulation Promotes Robustness to Fluctuations
in Production
Positive auto-regulation speeds responses and widens cell-cell
variability
Summary

THE FEEDFORWARD LOOP NETWORK MOTIF
Introduction
The Number of Appearances of a Subgraph in Random
Networks
The Feedforward Loop (FFL) is a Network Motif
The Structure of the Feedforward Loop Circuit
Dynamics of the Coherent FFL with AND-Logic
The C1-FFL is a Sign-Sensitive Delay Element
The Incoherent FFL: a pulse generator and response accelerator
Why Are Some FFL Types Rare?
Convergent Evolution of FFLs
Summary

TEMPORAL PROGRAMS AND THE GLOBAL STRUCTURE OF TRANSCRIPTION NETWORKS
Introduction
The Single-Input Module (SIM) Network Motif
SIMs Can Generate Temporal Expression Programs
Topological Generalizations of Network Motifs
The Multi-Output FFL Can Generate FIFO Temporal Order
Signal Integration and Combinatorial Control: Bi-Fans and
Dense-Overlapping Regulons
Network Motifs and the Global Structure of Sensory
Transcription Networks

NETWORK MOTIFS IN DEVELOPMENTAL, SIGNAL-TRANSDUCTION AND NEURONAL
NETWORKS
Introduction
Network Motifs in Developmental Transcription Networks:
Positive feedback loops and bistability
Motifs in Signal Transduction Networks
Information Processing Using Multi-Layer Perceptrons
Composite Network Motifs: Negative Feedback and Oscillator
Motifs
Network Motifs in the Neuronal Network of C. Elegans
Summary

ROBUSTNESS OF PROTEIN CIRCUITS, THE EXAMPLE OF BACTERIAL CHEMOTAXIS
The Robustness Principle
Bacterial Chemotaxis, or How Bacteria 'Think'
The Chemotaxis Protein Circuit of E. coli
Two Models Can Explain Exact Adaptation, One is Robust and
the Other Fine Tuned
The Barkai-Leibler model
Individuality and Robustness in Bacterial Chemotaxis

ROBUST PATTERNING IN DEVELOPMENT
Introduction to Morphogen Gradients
Exponential Gradients Are Not Robust
Increased Robustness by Self-Enhanced Morphogen
Degradation
Network Motifs That Provide Robust Patterning
The Robustness Principle Can Distinguish Between
Mechanisms of Fruit Fly Patterning

KINETIC PROOFREADING
Introduction
Kinetic Proofreading of the Genetic Code Can Reduce Error
Rates of Molecular Recognition
Recognition of Self and Non-Self by the Immune System
Kinetic Proofreading May Occur in Diverse Recognition
Processes in the Cell

OPTIMAL GENE CIRCUIT DESIGN
Introduction
Cost and Benefit Analysis of Gene circuits
Optimal Expression Level of a Protein Under Constant
Conditions
To Regulate or Not to Regulate: Optimal Regulation in Variable
Environments
Environmental Selection of the Feedforward Loop Network Motif
Summary

DEMAND RULES FOR GENE REGULATION
Introduction
The Savageau Demand Rules
Rules for Gene Regulation Based on Minimal Error Load
Demand Rules for Genes with Multiple Regulators
Summary

EPILOGUE: Simplicity in Biology

APPENDIX A: The Input-Function of a Gene, Michaelis-Menten and Hill
Equations

APPENDIX B: Multi-Dimensional Input-Functions

APPENDIX C: Graph Properties of Transcription Networks

APPENDIX D: Cell-Cell Variability in Gene Expression

GLOSSARY

BIBLIOGRAPHY

-----------------------------------------------------------
Uri Alon
Depts. Molecular Cell Biology and Physics of Complex Systems
Weizmann Institute of Science
Rehovot Israel 76100
www.weizmann.ac.il/mcb/UriAlon
FAX: 972-8-934-4125 Tel: 972-8-934-4448

NEW BOOK: An Introduction to Systems Biology (CRC press,2006)

See: www.weizmann.ac.il/mcb/UriAlon