Thursday, March 27, 2008

Jellyfish ?

Someone told me she likes this image, because "amazing how it looks like a Jellyfish! It's really great."



What do you think???

This is a monopolar Hela cells proceeding cytokinesis, where Aurora-B (red) relocates beyond microtubule (green) to the space between microtubules and the cortex.
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4 comments:

Anonymous said...

So is this "it"?

3/27/2008 11:12 PM
Red said...

Yap this is "it".

3/28/2008 9:39 AM
Anonymous said...

Why the Aurora-B has the tsaining pattern of speckles? What is the nature of cortex?

3/29/2008 1:24 AM
Red said...

Wow!

Aurora B, with other passenger proteins, relocalizes from kinetochores to midzone and the furrow cortex after anaphase starts.

Aurora B is transported to the microtubule plus ends by MKLP2 which explains why it's in the central region of midzone. But how it goes to the cortex is still a mystery. Here we showed Aurora B actually can move further beyond microtbule tips to the cortex (through actin filaments, not shown in this image). And we believe it is the mechanism relocalizing Aurora B to the furrow cortex.

The function of Aurora B during cytokinesis is still not very clear, espeically the cortical part. It is essential, but its multiple functions during mitosis and cytokinesis also make it harder to tackle by approaches such as genetics or RNAi.

3/29/2008 9:41 AM

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